Argania spinosa Leaves and Branches: Antiaggregant, Anticoagulant, Antioxidant Activities and Bioactive Compounds Quantification

Thrombocytes, also known as platelets, are crucial in maintaining the balance between blood clotting. Platelet hyperactivity and oxidative stress primary factors contributing to cardiovascular complications. Antithrombotic therapy remains one of most effective treatments, but various potential side effects hinder its effectiveness, including risk haemorrhage. Intense research has been conducted on medicinal plants discover natural antithrombotic compounds. Argania spinosa, commonly argan tree or oil tree, is a native species southwestern Morocco. This study evaluated secondary hemostasis antioxidant activity leaf branch aqueous extracts A. spinosa assessed phytochemical composition these extracts. aggregation assay was performed using washed platelets stimulated with thrombin. For plasmatic coagulation, activated partial thromboplastin time prothrombin were measured poor plasma method. Bleeding by inducing bleeding at tip mouse tail. The determined through DPPH, β-carotene, FRAP methods. presence absence metabolites carried out help specific reagents, quantitative analysis spectrophotometric colorimetric results revealed phenols, total flavonoids, cardiac glycosides, tannins, coumarins type both types higher concentration recorded leaves Both significantly reduced vitro thrombin-induced platelet aggregation, extended tail time, prolonged exhibited remarkable activity. extract exerts significant against thrombotic manifestations could be promising source new